The Eagles have already soundly beaten the Cavaliers this season and come into the ACC Tournament on a hot streak.
Charlotte North failed to register a point for just the second time in her BC career as Syracuse took a commanding early and won 16-7.
Thanks to four goals each from Belle Smith and Charlotte North, No. 5 Boston College lacrosse took down No. 4 Notre Dame on Thursday.
Louisville led 12-9 midway through the second half but BC fought back to tie the game with nine minutes to play and won 14-13 in OT.