Jenn Medjid tied the Boston College lacrosse record for goals in a single game with nine, lifting the Eagles over Louisville.
Louisville led 12-9 midway through the second half but BC fought back to tie the game with nine minutes to play and won 14-13 in OT.
Charlotte North led Boston College lacrosse to a 20-11 win over Virginia on Saturday. Virginia is the highest-ranked opponent that BC has beaten this season.
Boston College lacrosse held No. 18 UMass scoreless for 28 minutes en route to a 19-7 victory.
Attacker Charlotte North, who starred for Duke in 2019, as well as goaltender Rachel Hall and attacker Bridget Simmons, will join BC lacrosse for the 2020 season, Acacia Walker-Weinstein announced Tuesday.