The Eagles allowed 12 innings in the eighth inning to fall 13-9 in the second game of the doubleheader after dropping the first contest 5-2.
BC pieced together three hits in the ninth but it was not enough to overcome its earlier struggles and the Eagles lost 6-4.
Boston College baseball beat Virginia Tech 7-3 Thursday for its first series-opening win since early March.
Boston College baseball lost 16-12 to Clemson on Friday in an offensive, back and forth battle to start the three-game series.
Boston College baseball is winning games and breaking records, but the Eagles are still short of their full potential. BC is good and its ceiling has not yet been reached.
Walks and all-around sloppy play cost BC Friday in its loss to Louisville. The Eagles scored three runs in the first two innings off errors but were shut out for the remainder of the game.
Boston College baseball defeated Auburn 8-2 Friday. The Eagles combined for four home runs behind a strong pitching performance by Mason Pelio.