BC shot a season-low 30 percent from the field and had just one player in double digits, resulting in a blown eight-point second quarter lead and its first loss.
Emma Guy had 15 points and BC turned a seven-point game at halftime into a 26-point rout, its fourth win by 20-plus points in its first five games.
The Eagles trailed by two points after the first quarter, but were nothing but dominant from then on, outscoring the visiting Crusaders by 28 points en route to their third win in a row.
The schedule features a non-conference portion highlighted by local rivals Holy Cross and BU, as well as the always-tough ACC slate, which includes games against two teams who made the Final Four last season: Louisville and Notre Dame
The Eagles trailed by nine after one quarter, fought their way back into it, but were ultimately handed a fourth ACC tournament opening-round loss in five years by North Carolina.
Looking to advance to the second round of the ACC tournament for the second time in three years, the Eagles face a North Carolina team that they beat by 13 earlier in the year.